The way things went Sunday for the Bills, they may as well not have boarded the plane.
A week after a historic second half collapse vs the Patriots, the Bills were slammed by the Niners in San Fran 45-3 to drop their 2012 mark to 2-3 after five games.
Ryan Fitzpatrick finished with just 126 yards and an interception for Buffalo, which came in with an NFL-high 16 touchdowns but gained just 10 first downs in its second straight debilitating setback.
The Bills gave up 45 second-half points in last week’s loss to the Patriots and again had no answer for a 49ers team clicking on all cylinders.
“Obviously there’s something I’m not doing correctly with this football team in the second half, because we’ve played extremely poorly, and that’s as nice as you could put it, in the second half,” Bills head coach Chan Gailey said. “I don’t have the answers today. I have to find the answers.”
Sunday’s game shifted five minutes into the second quarter when Smith found Kyle Williams down the right sideline. Williams was tightly covered, but came back for the underthrown pass and made two defenders miss en route to a 43- yard TD that broke a 3-3 tie.
The Bills had no answers for 49′ers QB Alex Smith, who was nearly perfect through the air. Frank Gore had his way on the ground and the 49ers defense again kept the opposition out of the end zone for the second straight week.
Smith connected on 18-of-24 passes for 303 yards and three touchdowns, while Gore ran for 106 yards and a score on 14 carries for the 49ers (4-1), who gained a franchise-record 621 yards in their second straight blowout victory.
The Bills are back out west next Sunday as they take on the Arizona Cardinals.